An X-ray absorption spectroscopic study at the mercury LIII edge on phenylmercury(II) oxygen species

The X-ray absorption spectra of the reference and model compounds HgCl2, PhHgCl, PhHgOAc and [(PhHg)2OH][BF4].H2O have been analysed in both the XANES and EXAFS regions, and the technique was extended to determine the structures of (PhHg)2O, PhHgOH, and the basic salts PhHgOH.PhHgNO3 and PhHgOH.(PhHg)2SO4, which were previously structurally uncharacterised. Results indicate that (PhHg)2O is a molecular species with Hg-O-Hg 135°, while PhHgOH contains the [(PhHg)2OH]+ cation and is better formulated as [(PhHg)2OH]OH. The same cation is also featured in the two basic salts. Electrospray mass spectral studies of PhHgOH in aqueous solutions show that [PhHgOH2]+, [(PhHg)2OH]+ and [(PhHg)3O]+ co-exist in solution in a pH-dependent equilibrium

Effects of a multi-component exercise program and calcium–vitamin-D3-fortified milk on bone mineral density in older men : a randomised controlled trial

Summary We examined the independent and combined effects of a multi-component exercise program and calcium&ndash;vitamin-D3-fortified milk on bone mineral density (BMD) in older men. Exercise resulted in a 1.8% net gain in femoral neck BMD, but additional calcium&ndash;vitamin D3 did not enhance the response in this group of older well-nourished men.Introduction This 12-month randomised controlled trial assessed whether calcium&ndash;vitamin-D3-fortified milk could enhance the effects of a multi-component exercise program on BMD in older men.Methods Men (n&thinsp; =&thinsp;180) aged 50&ndash;79 years were randomised into: (1) exercise + fortified milk; (2) exercise; (3) fortified milk; or (4) controls. Exercise consisted of high intensity progressive resistance training with weight-bearing impact exercise. Men assigned to fortified milk consumed 400 mL/day of low fat milk providing an additional 1,000 mg/day calcium and 800 IU/day vitamin D3. Femoral neck (FN), total hip, lumbar spine and trochanter BMD and body composition (DXA), muscle strength 25-hydroxyvitamin D and parathyroid hormone (PTH) were assessed.Results There were no exercise-by-fortified milk interactions at any skeletal site. Exercise resulted in a 1.8% net gain in FN BMD relative to no-exercise (p&thinsp;&lt;&thinsp;0.001); lean mass (0.6 kg, p&thinsp;&lt;&thinsp;0.05) and muscle strength (20&ndash;52%, p&thinsp;&lt;&thinsp;0.001) also increased in response to exercise. For lumbar spine BMD, there was a net 1.4&ndash;1.5% increase in all treatment groups relative to controls (all p&thinsp;&lt;&thinsp;0.01). There were no main effects of fortified milk at any skeletal site.Conclusion A multi-component community-based exercise program was effective for increasing FN BMD in older men, but additional calcium&ndash;vitamin D3 did not enhance the osteogenic response.<br /

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes.

Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under voltage-clamp conditions, only homomeric rP2X(2) receptors were fully functional and gave rise to large inward currents (2-3 microA) to extracellular ATP. Coexpression of rP2X(2) and rP2X(6) subunits in Xenopus oocytes resulted in a heteromeric rP2X(2/6) receptor, which showed a significantly different phenotype from the wild-type rP2X(2) receptor. Differences included reduction in agonist potencies and, in some cases (e.g., Ap(4)A), significant loss of agonist activity. ATP-evoked inward currents were biphasic at the heteromeric rP2X(2/6) receptor, particularly when Zn(2+) ions were present or extracellular pH was lowered. The pH range was narrower for H(+) enhancement of ATP responses at the heteromeric rP2X(2/6) receptor. Also, H(+) ions inhibited ATP responses at low pH levels (<pH 6.3). The pH-dependent blocking activity of suramin was changed at this heteromeric receptor, although the potentiating effect of Zn(2+) on ATP responses was unchanged. Thus, the rP2X(2/6) receptor is a functionally modified P2X(2)-like receptor with a distinct pattern of pH modulation of ATP activation and suramin blockade. Although homomeric P2X(6) receptors function poorly, the P2X(6) subunit can contribute to functional heteromeric P2X channels and may influence the phenotype of native P2X receptors in those cells in which it is expressed

Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders

The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.Accepted manuscrip

Constraints on small-scale cosmological perturbations from gamma-ray searches for dark matter

Events like inflation or phase transitions can produce large density perturbations on very small scales in the early Universe. Probes of small scales are therefore useful for e.g. discriminating between inflationary models. Until recently, the only such constraint came from non-observation of primordial black holes (PBHs), associated with the largest perturbations. Moderate-amplitude perturbations can collapse shortly after matter-radiation equality to form ultracompact minihalos (UCMHs) of dark matter, in far greater abundance than PBHs. If dark matter self-annihilates, UCMHs become excellent targets for indirect detection. Here we discuss the gamma-ray fluxes expected from UCMHs, the prospects of observing them with gamma-ray telescopes, and limits upon the primordial power spectrum derived from their non-observation by the Fermi Large Area Space Telescope.Comment: 4 pages, 3 figures. To appear in J Phys Conf Series (Proceedings of TAUP 2011, Munich

Testing for Features in the Primordial Power Spectrum

Well-known causality arguments show that events occurring during or at the end of inflation, associated with reheating or preheating, could contribute a blue component to the spectrum of primordial curvature perturbations, with the dependence k^3. We explore the possibility that they could be observably large in CMB, LSS, and Lyman-alpha data. We find that a k^3 component with a cutoff at some maximum k can modestly improve the fits (Delta chi^2=2.0, 5.4) of the low multipoles (l ~ 10 - 50) or the second peak (l ~ 540) of the CMB angular spectrum when the three-year WMAP data are used. Moreover, the results from WMAP are consistent with the CBI, ACBAR, 2dFGRS, and SDSS data when they are included in the analysis. Including the SDSS galaxy clustering power spectrum, we find weak positive evidence for the k^3 component at the level of Delta chi' = 2.4, with the caveat that the nonlinear evolution of the power spectrum may not be properly treated in the presence of the k^3 distortion. To investigate the high-k regime, we use the Lyman-alpha forest data (LUQAS, Croft et al., and SDSS Lyman-alpha); here we find evidence at the level Delta chi^2' = 3.8. Considering that there are two additional free parameters in the model, the above results do not give a strong evidence for features; however, they show that surprisingly large bumps are not ruled out. We give constraints on the ratio between the k^3 component and the nearly scale-invariant component, r_3 < 1.5, over the range of wave numbers 0.0023/Mpc < k < 8.2/Mpc. We also discuss theoretical models which could lead to the k^3 effect, including ordinary hybrid inflation and double D-term inflation models. We show that the well-motivated k^3 component is also a good representative of the generic spikelike feature in the primordial perturbation power spectrum.Comment: 23 pages, 6 figures; added new section on theoretical motivation for k^3 term, and discussion of double D-term hybrid inflation models; title changed, added a new section discussing the generic spikelike features, published in IJMP

Platinum(II) phosphonate complexes derived from endo-8-camphanylphosphonic acid

The reactions of cis-[PtCl₂L₂] [L = PPh₃, PMe₂Ph or L₂ = Ph₂P(CH₂)₂PPh₂ (dppe)] with endo-8-camphanylphosphonic acid (CamPO₃H₂) and Ag₂O in refluxing dichloromethane gave platinum(II) phosphonate complexes [Pt(O₃PCam)L₂]. The X-ray crystal structure of [Pt(O₃PCam)(PPh₃)₂]•₂CHCl₃ shows that the bulky camphanyl group, rather than being directed away from the platinum, is instead directed into a pocket formed by the Pt and the two PPh₃ ligands. This allows the O₃P–CH₂ group to have a preferred staggered conformation. The complexes were studied in detail by NMR spectroscopy, which demonstrates non-fluxional behaviour for the sterically bulky PPh₃ and dppe derivatives, which contain inequivalent phosphine ligands in their ³¹P NMR spectra. These findings are backed up by theoretical calculations on the PPh₃ and PPhMe₂ derivatives, which show, respectively, high and low energy barriers to rotation of the camphanyl group in the PPh₃ and PPhMe₂ complexes. The X-ray crystal structure of CamPO₃H₂ is also reported, and consists of hydrogen-bonded hexameric aggregates, which assemble to form a columnar structure containing hydrophilic phosphonic acid channels surrounded by a sheath of bulky, hydrophobic camphanyl groups

Tomographic Characterization of a Multifunctional Composite High-Impedance Surface

© 1963-2012 IEEE. The performance of a multifunctional composite high-impedance surface (HIS) has been evaluated using the coherent Doppler tomography (CDT) and finite-impulse response (FIR) filtering techniques. A combination of embroidery and advanced laser manufacturing processes were used to fabricate the conformable multifunctional glass fiber reenforced polymer HIS. The CDT method was utilized because it enabled the generation of a high-resolution tomographic map of the HIS reflectivity. Tomograms generated at high incidence angles (>80° from normal) were used to localize and FIR filter unwanted scattering associated with the ground plane edges and HIS transition regions. The resulting scattered fields from a defect (metallic block positioned in the center of the tomogram) were then used to gain a significantly distinctive insight into the HIS scattering properties. Furthermore, unlike traditional methods for characterizing HISs, the CDT and FIR methods presented herein are applicable to electrically large and conformal HISs

The rings of Uranus: Results of the 10 April 1978 occultation

Observations of the 10 April 1978 stellar occultation by the rings of Uranus are presented. Nine rings were observed and their radii and widths are calculated. Rings η,y, and δ are found to be most likely circular and coplanar, in agreement with previous analyses; the remaining rings are either noncircular or slightly inclined. The width of the є ring is a linear function of its radius from the center of Uranus, projected onto the satellites' orbital plane; this suggests that it forms one continuous noncircular ring. The optical depth profile of the є ring has not changed significantly since March 1977. A model of this ring which fits all available observations adequately is that of a uniformly precessing Keplerian ellipse coplanar with the satellites' orbits. This model permits predictions of the radius and width of the є ring for future occultations. The precession rate is used to determine J_2 for Uranus, on the assumption that precession is caused solely by the planetary oblateness and not by satellite-ring interactions

Object knowledge modulates colour appearance

We investigated the memory colour effect for colour diagnostic artificial objects. Since knowledge about these objects and their colours has been learned in everyday life, these stimuli allow the investigation of the influence of acquired object knowledge on colour appearance. These investigations are relevant for questions about how object and colour information in high-level vision interact as well as for research about the influence of learning and experience on perception in general. In order to identify suitable artificial objects, we developed a reaction time paradigm that measures (subjective) colour diagnosticity. In the main experiment, participants adjusted sixteen such objects to their typical colour as well as to grey. If the achromatic object appears in its typical colour, then participants should adjust it to the opponent colour in order to subjectively perceive it as grey. We found that knowledge about the typical colour influences the colour appearance of artificial objects. This effect was particularly strong along the daylight axis